Yes, PAD is a serious condition. Clogged arteries cause decreased blood flow to the legs, which can result in pain when walking. If left untreated, plaque can form clots that block blood flow altogether. This stage of the disease causes critical limb ischemia (CLI) with leg pain that is severe enough to wake patients up at night.
Severe peripheral arterial disease can lead to foot sores or wounds on feet that do not heal. The condition can eventually even lead to gangrene and foot or leg amputation. Gangrene is dead tissue that must be removed quickly, or patients could lose a leg.
PAD can damage tissues and nerves in the legs and increase risk factors for stroke and heart attack. Without treatment, peripheral arterial disease can be fatal.